Rubymotion is built around a slightly restricted ruby that compiles to llvm. A non iOS focused version would seem to fit the criteria. Along similar lines, Uni

Rubymotion is built around a slightly restricted ruby that compiles to llvm. A non iOS focused version would seem to fit the criteria. Along similar lines, Unity uses a slightly restricted JavaScript than compiles to Mono's CLR implementation, as well as Boo, which is a Python-like language that also compiles to Mono. Iron Python, of which I have no direct experience, is another example. And of course there's Clojure if you're so inclined.