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For the curious, the LD50 in humans is thought to be somewhere on the order of 200mg/kg. So for a 70kg individual, that would be 14,000 mg (14 grams). A very st
by fbdab103 3y ago
For the curious, the LD50 in humans is thought to be somewhere on the order of 200mg/kg. So for a 70kg individual, that would be 14,000 mg (14 grams). A very strong coffee is 100mg, with energy drinks being 200-300mg.
- michaelmrose 3y agoIt's horrifyingly high right. That said people with some underlying medical conditions can succumb to far less. See the case where Panera Bread sold large caffeinated lemon-aid with unlimited refills
- chihuahua 3y agoThere is a ChubbyEmu video [0] where someone has a large container of powdered caffeine, and he accidentally takes a whole scoop of it - 35 grams. [0] https://www.youtube.com/watch?v=sylqJ0NEVJw https://www.youtube.com/watch?v=sylqJ0NEVJw
- SlightlyLeftPad 3y agoLD50 just means that’s when 50 percent of people die right? Someone may well die long before they hit 14g but I get the point. That’s still a crap load of caffeine my word.
- palmfacehn 3y agoI believe LD50 is measured with lab rats and proportional to body weight.
- razakel 3y agoLD50 is usually rat dosage unless there exists sufficient evidence to establish a value for humans. Ethics committees frown on poisoning people just to figure out how much is lethal.
- waswaswas 3y ago8oz of Starbucks’ bestselling Pike’s Place Roast is 150mg, and between different roasts and sizes, you can buy a drip coffee at Starbucks that has nearly 500mg of caffeine.
- fbdab103 3y agoHeh, yeah, I was considering home brew coffee. Measurements do not apply if you get the grande quad espresso.
- MobiusHorizons 3y agoContrary to popular belief espresso is not that high in caffeine compared to how much of it you would typically drink. When dilluted with milk or water back down to regular strength (by flavor) it is actually usually lower in caffeine than a typical medium roast drip. Light roast can be very high especially if you brew at 60g of coffee per liter of water that seems to have become popular with internet coffee enthusiasts.
- michaelmrose 3y agoI had to convert it I think that is around 1/4 cup per 6 cups (6 oz for some reason on coffee makers) . I use twice that but measured in dry beans. Is that really that much?
- MobiusHorizons 3y agoI think your conversion may be wrong. 60g per liter is 15g for 250ml (which is a small mug of coffee). At least with my coffee 15g occupies most of the quarter cup scoop I have been using. The flavor is good at that strength, but it’s a lot of caffeine. In the ballpark of 200mg depending on the beans and how well your brew method extracts it. 200mg is fine on its own but most people drink a few cups in a day.
- lupire 3y agoReferring to LD50 is insane, isn't it? LD10 is plenty for me never touch it outside of a life threatening emergency.
- fbdab103 3y agoSure, but you have to pick a threshold somewhere. Going with the median seems likely to be the most robust measurement. Which is to say, no, I would not feel comfortable consuming the equivalent LD49 of a substance. It is an order of magnitude estimate to give you a sense of toxicity. Which in the case of caffeine - is so high that it is nearly impossible for a healthy individual to consume that much accidentally.