3 ms·

But really, shoot up some Lidocaine/analogues: https://onlinelibrary.wiley.com/doi/10.1111/odi.14819?af=R#:~:text=Lidocaine%20exhibited%20suppressive%20effects%

But really, shoot up some Lidocaine/analogues: https://onlinelibrary.wiley.com/doi/10.1111/odi.14819?af=R#:~:text=Lidocaine%20exhibited%20suppressive%20effects%20on,stability%20by%20decreasing%20IGF2BP2%20levels https://onlinelibrary.wiley.com/doi/10.1111/odi.14819?af=R#:.... (Anticancer role of lidocaine in oral squamous cell carcinoma through IGF2BP2-mediated CAV1 stability)

pavel_lishin 3y ago
Don't forget to give her Smeckler's Powder.
A_D_E_P_T 3y ago
That's an in vitro study, in isolated cells, which used a totally non-physiological dose of lidocaine. It's not even a mouse or rat study. It's less valuable than that. Lidocaine, taken systemically, is associated with serious side effects. It's the only known "cure" for tinnitus, but its side effect profile is so nasty that pretty much nobody uses it. Don't give irresponsible advice.
- Khelavaster 3y ago
  That's a single in vitro study which represents Lidocaine's well-studied effects on certain kinds of cancers. Locally-delivered lidocaine to SCC-diseased oral areas and tumorous lymph nodes is totally feasible.
  - A_D_E_P_T 3y ago
    Feasible, maybe. But has it ever been done before? Are you aware of any papers where lidocaine is used as a treatment for solid tumors, and not simply as an analgesic during or following surgery? Studies in humans would be most relevant, but I'd even be interested in rodent studies if lidocaine is used systemically. (i.e. given orally or injected IP/SC/IV. Having researchers inject lidocaine directly into mouse tumors is not terribly relevant to what you were recommending.)
- Khelavaster 3y ago
  Your post is also mistaken. The study tested "In vivo tumor growth...using a tumor xenograft model." It's humanized tumors in mice with humanized immune systems. Totally a mouse/rat study. Don't be the guy who misleads researchers and sick people out of deep ignorance.
- pavel_lishin 3y ago
  About half of health-related HN submissions feature someone willing to throw out wild medical advice. They'll usually double down, too, by linking to a study - a study that neither they, or 99% of commenters, are capable of effectively evaluating. Treat them the same as you would that one weird guy who tells you that drinking urine will cure everything that ails you.

pavel_lishin 3y ago

Don't forget to give her Smeckler's Powder.

A_D_E_P_T 3y ago

That's an in vitro study, in isolated cells, which used a totally non-physiological dose of lidocaine. It's not even a mouse or rat study. It's less valuable than that. Lidocaine, taken systemically, is associated with serious side effects. It's the only known "cure" for tinnitus, but its side effect profile is so nasty that pretty much nobody uses it. Don't give irresponsible advice.

Khelavaster 3y ago
That's a single in vitro study which represents Lidocaine's well-studied effects on certain kinds of cancers. Locally-delivered lidocaine to SCC-diseased oral areas and tumorous lymph nodes is totally feasible.
- A_D_E_P_T 3y ago
  Feasible, maybe. But has it ever been done before? Are you aware of any papers where lidocaine is used as a treatment for solid tumors, and not simply as an analgesic during or following surgery? Studies in humans would be most relevant, but I'd even be interested in rodent studies if lidocaine is used systemically. (i.e. given orally or injected IP/SC/IV. Having researchers inject lidocaine directly into mouse tumors is not terribly relevant to what you were recommending.)
Khelavaster 3y ago
Your post is also mistaken. The study tested "In vivo tumor growth...using a tumor xenograft model." It's humanized tumors in mice with humanized immune systems. Totally a mouse/rat study. Don't be the guy who misleads researchers and sick people out of deep ignorance.
pavel_lishin 3y ago
About half of health-related HN submissions feature someone willing to throw out wild medical advice. They'll usually double down, too, by linking to a study - a study that neither they, or 99% of commenters, are capable of effectively evaluating. Treat them the same as you would that one weird guy who tells you that drinking urine will cure everything that ails you.