4 ms·

The study is called "Phosphodiesterase Type 5 Inhibitors in Men With Erectile Dysfunction and the Risk of Alzheimer Disease" and published in "Neurology", for r

The study is called "Phosphodiesterase Type 5 Inhibitors in Men With Erectile Dysfunction and the Risk of Alzheimer Disease" and published in "Neurology", for reference. It's open access, link: https://doi.org/10.1212/WNL.0000000000209131 https://doi.org/10.1212/WNL.0000000000209131

A_D_E_P_T 3y ago
All in all, it's not too surprising. The paper mentions neuroprotective effects, but it has been known for a while that nearly all types of PDE inhibitor can boost cognitive function, which has led to some interest in them as nootropics: https://pubmed.ncbi.nlm.nih.gov/25464010/ https://pubmed.ncbi.nlm.nih.gov/25464010/ There has been some interest in PDE5 inhibitors, specifically, as treatments for Alzheimer's: https://www.sciencedirect.com/science/article/abs/pii/S0361923019304319 https://www.sciencedirect.com/science/article/abs/pii/S03619... And, in a 20 year old paper, a PDE5 inhibitor appears to have direct effects on memory consolidation in an animal model: https://pubmed.ncbi.nlm.nih.gov/15312986/ https://pubmed.ncbi.nlm.nih.gov/15312986/ So, yeah, if I fancied myself at risk for dementia, I don't think it would be unwise to take viagra or sildenafil as a precautionary neuroprotective measure.
- wil421 3y ago
  Does the main Viagra side effect have anything to do with it? A little more action might be helping too.
- brnt 3y ago
  Can women take viagra too? For the same cognitive effect?
  - A_D_E_P_T 3y ago
    Yes. It's also used in neonates, both male and female, for its ability to treat pulmonary hypertension -- but also, it is now emerging, for its neuroprotective properties: https://www.frontiersin.org/articles/10.3389/fncel.2022.879649/full https://www.frontiersin.org/articles/10.3389/fncel.2022.8796... From the same paper, there's some indication that its cognitive effects might be more potent in women, as "[s]everal studies have suggested that sex hormones may influence the effects of sildenafil on the brain. Female mice performed significantly better than males after sildenafil treatment following HI insult, which suggests a sex-dependent effect of sildenafil (Engels et al., 2017). The underlying mechanism might be related to the relationship between sex hormones and the NO/cGMP pathway."
- wslh 3y ago
  I also recommend to check the /r/nootropics subreddit threads [1] on the topic. [1] https://www.reddit.com/r/Nootropics/search?q=Phosphodiesterase&restrict_sr=on&include_over_18=on https://www.reddit.com/r/Nootropics/search?q=Phosphodiestera...

A_D_E_P_T 3y ago

All in all, it's not too surprising. The paper mentions neuroprotective effects, but it has been known for a while that nearly all types of PDE inhibitor can boost cognitive function, which has led to some interest in them as nootropics: https://pubmed.ncbi.nlm.nih.gov/25464010/ https://pubmed.ncbi.nlm.nih.gov/25464010/ There has been some interest in PDE5 inhibitors, specifically, as treatments for Alzheimer's: https://www.sciencedirect.com/science/article/abs/pii/S0361923019304319 https://www.sciencedirect.com/science/article/abs/pii/S03619... And, in a 20 year old paper, a PDE5 inhibitor appears to have direct effects on memory consolidation in an animal model: https://pubmed.ncbi.nlm.nih.gov/15312986/ https://pubmed.ncbi.nlm.nih.gov/15312986/ So, yeah, if I fancied myself at risk for dementia, I don't think it would be unwise to take viagra or sildenafil as a precautionary neuroprotective measure.

wil421 3y ago
Does the main Viagra side effect have anything to do with it? A little more action might be helping too.
brnt 3y ago
Can women take viagra too? For the same cognitive effect?
- A_D_E_P_T 3y ago
  Yes. It's also used in neonates, both male and female, for its ability to treat pulmonary hypertension -- but also, it is now emerging, for its neuroprotective properties: https://www.frontiersin.org/articles/10.3389/fncel.2022.879649/full https://www.frontiersin.org/articles/10.3389/fncel.2022.8796... From the same paper, there's some indication that its cognitive effects might be more potent in women, as "[s]everal studies have suggested that sex hormones may influence the effects of sildenafil on the brain. Female mice performed significantly better than males after sildenafil treatment following HI insult, which suggests a sex-dependent effect of sildenafil (Engels et al., 2017). The underlying mechanism might be related to the relationship between sex hormones and the NO/cGMP pathway."
wslh 3y ago
I also recommend to check the /r/nootropics subreddit threads [1] on the topic. [1] https://www.reddit.com/r/Nootropics/search?q=Phosphodiesterase&restrict_sr=on&include_over_18=on https://www.reddit.com/r/Nootropics/search?q=Phosphodiestera...