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Velorum Therapeutics: Powerful cancer drugs that starve tumors (YC W24)
- Khelavaster 3y agoThey build off of p53/SIRT heme regulation pathways... 1. Lidocaine seems to treat many cancers via hemeapoptosis and p53 pathway changes this same way, including ovarian & breast and oral SCC malignancies. (See: "Lidocaine Promoted Ferroptosis by Targeting miR-382-5p /SLC7A11 Axis in Ovarian and Breast Cancer" (2021) -https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8188239/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8188239/ and "Anticancer role of lidocaine in oral squamous cell carcinoma through IGF2BP2-mediated CAV1 stability" (2023) -https://pubmed.ncbi.nlm.nih.gov/38071190/ https://pubmed.ncbi.nlm.nih.gov/38071190/) === 2. Velorum Therapeutics should explicitly promote p53 pathway more. Many cellular experts still don't implicitly associate p53 (and SIRT + nk-fb) with heme metabolism.