4 ms·
The gene is called CYP1A2 with two variants. One variant is a rapid caffeine metabolizer. The other is a slow caffeine metabolizer. https://www.geneticlifehacks
by xcv123 3y ago
The gene is called CYP1A2 with two variants. One variant is a rapid caffeine metabolizer. The other is a slow caffeine metabolizer. https://www.geneticlifehacks.com/liver-detox-genes-cyp1a2/ https://www.geneticlifehacks.com/liver-detox-genes-cyp1a2/
I have the rapid variant but could not sleep well on 6 cups.
- JonChesterfield 3y agoThat is interesting information. I note that the same enzyme breaks down melatonin. If a variant that is particularly efficient at caffeine is also particularly efficient at breaking down melatonin, the symptom would be difficulty getting to sleep independent of amount of caffeine, which is totally fixed by taking melatonin tablets.
- b800h 3y agoSlow metaboliser here. If I drink a coffee at 11am my heart rate rises and doesn't return to normal until the following morning. There are other genes for it too, like one that affects the degree to which coffee causes anxiety. And plenty of others that we haven't found, presumably.
- op00to 3y agoI love love love love coffee. It took me years to realize that my high blood pressure was controlled almost immediately by cutting out a high-test canned “Draft Latte” drink. I can drink a single 8oz cup every few days. Decaf is fine.