3 ms·
> AI-protein design Any recommendations on learning how to do this? As well as the limitations to your approach? I've been interested in engineering site-speci
by anonymouskimmer 3y ago
> AI-protein design
Any recommendations on learning how to do this? As well as the limitations to your approach? I've been interested in engineering site-specific DNA binding proteins for over a decade now, but the tools I've looked at are specific for protein to small-molecule or protein to protein interfaces.
- deleted 3y ago[deleted]
- aabaker99 3y agoIf you’re up for reading a dissertation I have one in mind I can dig up. I will check back here in 12 hours or so or you can contact me from my profile.
- bettercaust 3y agoWould also be interested in this if you'd care to post publicly.
- anonymouskimmer 3y agoIn case you missed it: https://news.ycombinator.com/item?id=39283253 https://news.ycombinator.com/item?id=39283253
- anonymouskimmer 3y agoThat sounds great.
- aabaker99 3y agoIt turns out the dissertation is not quite published yet, but this paper [1] will be a part of it. Sam and I were in the same lab and his work has evolved to focus even more on AI-guided protein design. Perhaps the quote from the abstract that made the connection for me to this post: > We applied the protein G B1 domain (GB1) models to design a sequence that binds to immunoglobulin G with substantially higher affinity than wild-type GB1. [1] https://www.pnas.org/doi/pdf/10.1073/pnas.2104878118?download=true https://www.pnas.org/doi/pdf/10.1073/pnas.2104878118?downloa...
- anonymouskimmer 3y agoThank you very much!