Are you talking about https://en.wikipedia.org/wiki/Comair_Flight_5191 https://en.wikipedia.org/wiki/Comair_Flight_5191 in 2006? Note that this was a Bombardie

Are you talking about https://en.wikipedia.org/wiki/Comair_Flight_5191 https://en.wikipedia.org/wiki/Comair_Flight_5191 in 2006? Note that this was a Bombardier plane, not a Boeing, and it was the pilot taking the wrong runway, not a plane issue. (Whether to count it as "aboard a major airline" is a semantic question that isn't very interesting.)