You can use the tmux API or a plugin like tmuxp[1] to load a pre-configured session (including running arbitrary shell commands and setting layout). Using this

You can use the tmux API or a plugin like tmuxp[1] to load a pre-configured session (including running arbitrary shell commands and setting layout). Using this you could automatically spawn your ssh connections as nested tmux sessions. Obviously this brings some complications, namely that you need to set different prefix keys (or double press prefix) and any non-prefix hotkeys always get sent to your local session. Personally I just configure remote tmux to have only prefixed keybinds and never make any complicated layouts on remote sessions so that having to press <inner-prefix> + <key> doesn't get annoying. [1]: https://github.com/tmux-python/tmuxp https://github.com/tmux-python/tmuxp