A big issue is that the current milieu rewards pure weight loss over other outcomes. The obvious[1] thing to do is to reduce the dose so that the appetite loss

A big issue is that the current milieu rewards pure weight loss over other outcomes. The obvious[1] thing to do is to reduce the dose so that the appetite loss and consequent calorie deficit is in range of what is commonly recommended for weight loss[2] and prescribe resistance training to spare muscle as well as all its other health benefits. That said the bimagrumab results[4] are interesting [1] we would still want to do studies to confirm this, but all indications are that it would work as expected [2] 0.5-1% of bodyweight per month, or if you want to get fancy body fat percentage / 20[3] [3] https://www.strongerbyscience.com/realistic-training-goals/ https://www.strongerbyscience.com/realistic-training-goals/ [4] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7807292/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7807292/