3 ms·
> A tantalizing clue stemmed from men who have two X chromosomes and one Y chromosome, a rare condition called Klinefelter syndrome. These men run a much higher
by francisofascii 3y ago
> A tantalizing clue stemmed from men who have two X chromosomes and one Y chromosome, a rare condition called Klinefelter syndrome. These men run a much higher risk of suffering from autoimmune diseases, suggesting that the number of X chromosomes plays an important role.
Interesting. And apparently this is pretty common. Less than 1 in 1000 male births.
- lcnPylGDnU4H9OF 3y ago> Less than 1 in 1000 male births. Just for clarity: <1 in 1000 or; 1 in <1000? I assume the latter because the former is less obvious as "pretty common" given that <1 could be something like 1e-10, but it's not clear as written.
- francisofascii 3y agoYes. Sorry. 1 in <1000.
- lcnPylGDnU4H9OF 3y agoThanks for the reply! I did find my answer and forgot to include it here: > occurring in one to two per 1,000 live births https://en.wikipedia.org/wiki/Klinefelter_syndrome https://en.wikipedia.org/wiki/Klinefelter_syndrome
- phnofive 3y agoSpeaking of, here's a study showing a reduction (sort of) in autoimmunity in such persons following a course of TRT: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1905740/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1905740/