3 ms·

Fascinating. Maybe I’m misunderstanding, but I immediately have questions about whether sleep quality links with neurodegenerative disease are instead a symptom

Fascinating. Maybe I’m misunderstanding, but I immediately have questions about whether sleep quality links with neurodegenerative disease are instead a symptom of sleep apnea via reduced lymphatic stimulation and not sleep itself. Could diet impact it, not by the composition of the food, but by consistency and how much chewing is involved. Could chewing gum make a difference? Neck exercises? I wonder if there is a correlation with people who mouth breathe or clench their teeth at night.

shreezus 3y ago
There's been a lot of recent interest in mouth taping during sleep, which can help alleviate issues related to mouth breathing or snoring. Anecdotally I've seen improvement in overall sleep quality (quantified w/ a wearable device) when I use tape vs without.
- farmdve 3y ago
  How would that work for people with chronic stuffy nose due to stay a prior Staph infection and/or allergic reactions.
  - eurekin 3y ago
    I had a runny nose most of my life - diagnosed allergies and etc. One visit in laryngologist got me thinking; he said: "It's simple. Wet wounds heal fast and well. Dry ones can even not heal at all. You have dry lung mucosa and that's why you get infected easily: it's like an open wound". He was right, after keeping > 50% humidity around myself I got better. That got me thinking of experimenting more. What if, I had a running nose, because the body wanted to make my lungs less dry? So I forced myself to breath through nose for two weeks and again, got better. Still doing it, years after.
    - eurekin 3y ago
      Correction: up to 50. Without intervention it was closer to 28
NoPedantsThanks 3y ago
My dad has Parkinson's and has very poor-quality sleep. He also has had anti-snoring surgery in the past, and chronic post-nasal drip (which I also seem to have). This article raises questions in my mind as to whether any of these are related. Also interesting is this: "researchers were able to successfully modulate cervical lymphatics using phenylephrine (which activates α1-adrenergic receptors, causing smooth-muscle contraction)" Phenylephrine is the so-called decongestant that has finally been called out for being a fraud in oral medications (and I can tell you from painful, painful experience that it is indeed a fraud). I was surprised to see that it allegedly accomplishes something in this particular application. https://www.cnbc.com/2023/09/12/decongestant-phenylephrine-ineffective.html https://www.cnbc.com/2023/09/12/decongestant-phenylephrine-i...
- frankus 3y ago
  IIUC it’s the minimal bioavailability of it in pill form that’s the problem, but it works ok when injected.
  - akdor1154 3y ago
    Also works great as a nasal spray, which is getting coincidentally close to the original article..
  - NoPedantsThanks 3y ago
    [dead]
- andy_ppp 3y ago
  You could try other blood flow/nitric oxide enhancers, body builders use them to increase the pump https://www.ghostlifestyle.com/search?q=PUMP https://www.ghostlifestyle.com/search?q=PUMP. Or you could drink beetroot juice a few times per week. Who knows if this will work though. I have my suspicions that inversions are very good for brain health and blood flow and I sleep better if I do yoga before bed. I quite enjoy Sivananda yoga it’s fairly easy, reminds me of a beautiful time in their Ashram outside Madurai and you can see real progress because the basic routine is always the same. https://youtu.be/AN0fVx8gi8w https://youtu.be/AN0fVx8gi8w

shreezus 3y ago

There's been a lot of recent interest in mouth taping during sleep, which can help alleviate issues related to mouth breathing or snoring. Anecdotally I've seen improvement in overall sleep quality (quantified w/ a wearable device) when I use tape vs without.

farmdve 3y ago
How would that work for people with chronic stuffy nose due to stay a prior Staph infection and/or allergic reactions.
- eurekin 3y ago
  I had a runny nose most of my life - diagnosed allergies and etc. One visit in laryngologist got me thinking; he said: "It's simple. Wet wounds heal fast and well. Dry ones can even not heal at all. You have dry lung mucosa and that's why you get infected easily: it's like an open wound". He was right, after keeping > 50% humidity around myself I got better. That got me thinking of experimenting more. What if, I had a running nose, because the body wanted to make my lungs less dry? So I forced myself to breath through nose for two weeks and again, got better. Still doing it, years after.
  - eurekin 3y ago
    Correction: up to 50. Without intervention it was closer to 28

NoPedantsThanks 3y ago

My dad has Parkinson's and has very poor-quality sleep. He also has had anti-snoring surgery in the past, and chronic post-nasal drip (which I also seem to have). This article raises questions in my mind as to whether any of these are related. Also interesting is this: "researchers were able to successfully modulate cervical lymphatics using phenylephrine (which activates α1-adrenergic receptors, causing smooth-muscle contraction)" Phenylephrine is the so-called decongestant that has finally been called out for being a fraud in oral medications (and I can tell you from painful, painful experience that it is indeed a fraud). I was surprised to see that it allegedly accomplishes something in this particular application. https://www.cnbc.com/2023/09/12/decongestant-phenylephrine-ineffective.html https://www.cnbc.com/2023/09/12/decongestant-phenylephrine-i...

frankus 3y ago
IIUC it’s the minimal bioavailability of it in pill form that’s the problem, but it works ok when injected.
- akdor1154 3y ago
  Also works great as a nasal spray, which is getting coincidentally close to the original article..
- NoPedantsThanks 3y ago
  [dead]
andy_ppp 3y ago
You could try other blood flow/nitric oxide enhancers, body builders use them to increase the pump https://www.ghostlifestyle.com/search?q=PUMP https://www.ghostlifestyle.com/search?q=PUMP. Or you could drink beetroot juice a few times per week. Who knows if this will work though. I have my suspicions that inversions are very good for brain health and blood flow and I sleep better if I do yoga before bed. I quite enjoy Sivananda yoga it’s fairly easy, reminds me of a beautiful time in their Ashram outside Madurai and you can see real progress because the basic routine is always the same. https://youtu.be/AN0fVx8gi8w https://youtu.be/AN0fVx8gi8w