3 ms·
Scientists found a major clue why 4 of 5 autoimmune patients are women
- gardenfelder 3y agohttps://archive.ph/8ZUJm https://archive.ph/8ZUJm
- codersfocus 3y agoA molecule responsible for deactivating women’s second X chromosome is responsible
- thelastparadise 3y ago> Women typically have two X chromosomes Isn't this actually the definition of female?
- supertofu 3y agoTurner syndrome describes a biological female with just one X chromosome.
- TheCoelacanth 3y agoNo, there are cases where males have two X chromosomes[1][2], cases where females have more[3] or less[4] than two and of course trans-women who most commonly have XY chromosomes. [1] https://en.wikipedia.org/wiki/Klinefelter_syndrome https://en.wikipedia.org/wiki/Klinefelter_syndrome [2] https://en.wikipedia.org/wiki/XXYY_syndrome https://en.wikipedia.org/wiki/XXYY_syndrome [3] https://en.wikipedia.org/wiki/Trisomy_X https://en.wikipedia.org/wiki/Trisomy_X [4] https://en.wikipedia.org/wiki/Turner_syndrome https://en.wikipedia.org/wiki/Turner_syndrome
- altairprime 3y ago> > Women typically have two X chromosomes > Isn't this actually the definition of female? ‘Women’ and ‘female’ are not interchangeable; one is a gender characteristic, the other is a sex characteristic. The statement as made is valid: Women are statistically likely to be XX, rather than XY or XXY or no doubt many other variations. ‘XX is female’ is a convenient rubric that is easy to remember, but as is usual for such things, human bodies do not respect convenient rubrics regarding genetics and sexes.
- n8henrie 3y agoPerhaps you meant "'XX is female' is a convenient rubric"?
- altairprime 3y agoYep! Fixed, thanks.
- viisio 3y agoNo, they're both sex characteristics. It's just that there are individuals with sex chromosome aneuploidies who will develop a female phenotype, e.g. X0 (Turner syndrome) and XXX (trisomy X), and also XY individuals where the Y chromosome is deficient in specific ways, e.g. Swyer syndrome.
- tzs 3y ago> ‘Women’ and ‘female’ are not interchangeable; one is a gender characteristic, the other is a sex characteristic. That's not what most dictionaries say. They say a 'woman' is an adult female human.
- AussieWog93 3y agoCome on man. This article is about autoimmune diseases, not witty quips about trans women.
- francisofascii 3y ago> A tantalizing clue stemmed from men who have two X chromosomes and one Y chromosome, a rare condition called Klinefelter syndrome. These men run a much higher risk of suffering from autoimmune diseases, suggesting that the number of X chromosomes plays an important role. Interesting. And apparently this is pretty common. Less than 1 in 1000 male births.
- lcnPylGDnU4H9OF 3y ago> Less than 1 in 1000 male births. Just for clarity: <1 in 1000 or; 1 in <1000? I assume the latter because the former is less obvious as "pretty common" given that <1 could be something like 1e-10, but it's not clear as written.
- francisofascii 3y agoYes. Sorry. 1 in <1000.
- lcnPylGDnU4H9OF 3y agoThanks for the reply! I did find my answer and forgot to include it here: > occurring in one to two per 1,000 live births https://en.wikipedia.org/wiki/Klinefelter_syndrome https://en.wikipedia.org/wiki/Klinefelter_syndrome
- phnofive 3y agoSpeaking of, here's a study showing a reduction (sort of) in autoimmunity in such persons following a course of TRT: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1905740/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1905740/