There are SNPs that have significant clinical impact and alter the downstream translation and associated with poor outcome. https://www.ncbi.nlm.nih.gov/pmc/ar

There are SNPs that have significant clinical impact and alter the downstream translation and associated with poor outcome. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8129253/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8129253/ They could help in stratifying patients and strategically targeted therapy. They can't be easily targeted (drugged) drirectly but they could lead to therapeutics if I understand correctly.