5 ms·
> Note, however, that SNPs like the one you pointed out are relatively infrequent. If you mean that SNPs with small effect sizes don't always point to useful d
by carbocation 3y ago
> Note, however, that SNPs like the one you pointed out are relatively infrequent.
If you mean that SNPs with small effect sizes don't always point to useful drug targets with big druggable effects, that is possible, but this remains an open question and is the subject of intensive research right now.
- nextos 3y agoYes, I agree. The trick is probably to find cell-specific SNPs located in regulatory regions so that there are no off-target effects. Massive screens using single-cell perturbations will help to gain some insights.