Why don't they run an ethylene/propylene glycol solution loop (with refrigerant to-water heat exchanger integral to the compressor unit) like industrial chiller

Why don't they run an ethylene/propylene glycol solution loop (with refrigerant to-water heat exchanger integral to the compressor unit) like industrial chillers? There's a tiny loss in efficiency due to the extra heat exchanger and higher pumping losses, but you get less leakage, less refrigerant, your lines are unpressurized, etc. A lot more of the installation process could probably also be done with low-skill labor. I imagine it would also be easier to retrofit such a system into houses with existing in-floor radiant heating and/or baseboard radiators.