Exactly. Almost all dietary advice comes from personal anecdotes, because we have no studies. Almost none of it is backed by any high-quality evidence. Unfortun

Exactly. Almost all dietary advice comes from personal anecdotes, because we have no studies. Almost none of it is backed by any high-quality evidence. Unfortunately, it spreads on social media. It's actually really hard to study dietary impact on autoimmmune diseases. Dietary studies are hard, period. So they're generally not done. Almost all studies are based on self-reported questionnaires. The nightshade thing has no real basis in science. I don't know who came up with it, but it may have been Pagano — a chiropractor who provided no sources for his claims, nor had any medical training relevant to autoimmune diseases. There's admittedly one study that shows that glycoalkaloids like solanines (present in nightshades like potatoes) may aggravate Crohn's disease due to intestinal permeability [1], but we don't know if it applies to other autoimmunes like psoriasis (where disrupted permeability is present in more severe cases [2]) or RA. I can appreciate the "big pharma bad" point that drugs like biologics only treat the symptoms and not the underlying cause, because it seems like an insane amount of money is spent on drugs that basically "pave over" a pathology — like prescribing earbuds to drown out a squeaky wheel rather applying some lubricant — and not putting enough money into finding the cause. But even though it seems lopsided, until a cure is found, we have to be pragmatic; we need those drugs. (Of course, the argument also ignores the fact that most drugs in the world only treat symptoms. Nothing bad with that.) [1] https://pubmed.ncbi.nlm.nih.gov/12479649/ https://pubmed.ncbi.nlm.nih.gov/12479649/ [2] https://pubmed.ncbi.nlm.nih.gov/30222202/ https://pubmed.ncbi.nlm.nih.gov/30222202/