3 ms·

> Mast cells, histamines, allergies, and sensitivities are autoimmune areas They quite literally are not. Autoimmune diseases are, by definition, when the immu

• jph 3y ago
  I wrote autoimmune areas, not autoimmune diseases. If you're interested, here's more specifics about these areas, as explained in this recent research paper: Allergic Disease and Autoimmune Effectors Pathways (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2276104/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2276104/) Abstract: Allergy and autoimmunity result from dysregulation of the immune system. Until recently, it was generally accepted that the mechanisms that govern these disease processes are quite disparate; however, new discoveries suggest possible common pathogenetic effector pathways. This review illustrates the concomitant presentation of these conditions and the potential relationship or common mechanism in some cases, by looking at the key elements that regulate the immune response in both allergic and autoimmunite conditions: mast cells, antibodies, T cells, cytokines, and genetic determinants. The parallel appearance of allergic and autoimmune conditions in the some patients may reveal that such aberrations of the immune system have a common pathophysiologic mechanism. Mast cells, which play a key role in allergic reactions, and the wealth of inflammatory mediators they express, make it likely that they have profound effects on many autoimmune processes.