4 ms·
It would be nice if there was a link to the paper, if there is one, what the genetic modifications were, and what the points of failure were. Similar studies w
by pazimzadeh 3y ago
It would be nice if there was a link to the paper, if there is one, what the genetic modifications were, and what the points of failure were.
Similar studies with human blood have been done by my mom’s research group (https://www.massgeneral.org/transplant/cts/research/pierson-laboratory https://www.massgeneral.org/transplant/cts/research/pierson-...) with up to 850 minutes of perfusion with six genetic modifications to the pig liver. The main point of failure was that pig liver acts like a sponge for human platelets, which is not supposed to happen.
hEPCR.hTBM.hCD47.hHO-1 with donor clodronate and DDAVP treatment improves perfusion and function of GalTKO.hCD46 porcine livers perfused with human blood
https://pubmed.ncbi.nlm.nih.gov/35166407/ https://pubmed.ncbi.nlm.nih.gov/35166407/
The pig liver can also chop up human reb blood cells for unclear reasons:
Human erythrocyte fragmentation during ex-vivo pig organ perfusion
https://pubmed.ncbi.nlm.nih.gov/35112383/ https://pubmed.ncbi.nlm.nih.gov/35112383/
eGenesis in the Guardian article is a competitor to Revivicor, in the articles I linked.
My mom’s lab led in this area of research and when she was dying of cancer she wanted to be used for this type of experiment, but her wish wasn’t granted. It’s good to see that more people are willing to donate their body to this type of research. However it seems like the various groups working on xenotransplantation are more and more silo’d from each other instead of collaborating, which is sad.
- strangattractor 3y agoThink how much a solution to organ donation would be worth. Cash kills collaboration®