I think I've read somewhere that drop in blood glucose can cause headaches. Maybe sweetners trick your body into releasing a lot of insuline to deal with "sugar

I think I've read somewhere that drop in blood glucose can cause headaches. Maybe sweetners trick your body into releasing a lot of insuline to deal with "sugar" but there's no new sugar in your blood so glucose level drops giving you a headache? Just a theory but you could test it by monitoring glucose after ingesting something with sweetner. According to this theory ingesting sweetner together with sugar should cause you less or no discomfort. Maybe you could try doing something like drinking normal Coke after accidentally ingesting sweetner to see if it helps? Alcohol might be a different issue. After all it's just a straight up poison that metabolizes into another poison.