Depending on how you define America, use of psychedelics goes back a bit further than the 20th century, or the arrival of Europeans. For example, here's a nice

Depending on how you define America, use of psychedelics goes back a bit further than the 20th century, or the arrival of Europeans. For example, here's a nice overview of the history of mescaline, the active ingredient in peyote cactus: https://medicalhealthhumanities.com/2019/09/17/from-the-desert-to-the-laboratory-mike-jays-mescaline-a-global-history-of-the-first-psychedelic/ https://medicalhealthhumanities.com/2019/09/17/from-the-dese...