SSRIs are not placebo. They are very powerful drugs. Increasing the dosage has more extreme effects. To call it placebo is a misunderstanding of statistics. If

SSRIs are not placebo. They are very powerful drugs. Increasing the dosage has more extreme effects. To call it placebo is a misunderstanding of statistics. If a drug doesn’t work for 80% of people but works for 20% very well, it might be indistinguishable statistically from placebo. That doesn’t mean it isn’t working.