I would say that all modern "general purpose" ISAs (and microarchitectures) are optimized for C (and C++). That's what most OS:es and high profile applications

I would say that all modern "general purpose" ISAs (and microarchitectures) are optimized for C (and C++). That's what most OS:es and high profile applications are written in (web browsers - and by extension electron apps, compilers, games, content creation, etc).