As an expert, do you think this might lead to easier discovery of much more selective GPCR ligands? Agree finding new 5HT2A ligands is cool, what would be trul

As an expert, do you think this might lead to easier discovery of much more selective GPCR ligands? Agree finding new 5HT2A ligands is cool, what would be truly interesting is having a suite of totally selective ligands for the entire 5-HT receptor family. I feel like a lot psychopharmacological research into a lot of mental disorder is severely hampered by 1) the complex interactions of the various serotonin receptors(and also with other receptors like D2) 2) the lack of truly selective ligands, necessitating a hodge podge of less selective agonists combined with selective antagonists to isolate the effects of specific receptor interactions(making it hard to do this sort of thing in humans). Or using knockout mice, which is also kind of dubious because you've now made a fundamentally different brain and are trying to compare it to a normal one. And that's sort of hit and miss.