4 ms·
There are a ton of challenges to better oncology treatments. First, as many have noted, cancer is a constellation of diseases. Often a single tumor will contain
by bglazer 3y ago
There are a ton of challenges to better oncology treatments. First, as many have noted, cancer is a constellation of diseases. Often a single tumor will contain multiple different, but related groups of cells. So most treatments will only work for a subset of cancers, and then only until the cancer evolves to be resistant. So any advance, will be necessarily “modest”, the reality of the situation is that there will never be a silver bullet. The closest we’ve come is immunotherapies, the class of treatment described in the article. These are a legitimately incredible advance, completely curing many people without the side effects of chemo. That said, theyre limited because cancer can evolve to defeat the immune response, and occasionally the immune system either under or over-reacts.
Also if you think there’s no sense of urgency, you haven’t talked to anyone actually in the field. Do you really think oncologists (pediatric oncologists!) aren't eager to cure their patients?
- s1artibartfast 3y agoPlus there is the existing financial incentive. If an individual or company comes up with a revolutionary treatment, it would be an absolute money printer. Even historic improvements for large demographics have massive returns. Keytruda (major oncology improvement) had more than $20 billion sales in 2023. It is hard to think of a stronger market incentive to improve drugs as much as possible.
- mmaunder 3y ago> Do you really think oncologists (pediatric oncologists!) aren't eager to cure their patients? Don’t be bloody ridiculous.
- bglazer 3y ago> Feels like there’s an ossification of this entire sector that happened years ago and there’s no sense of urgency Ok, can you explain what you meant by this?