Certain biocides were a problem: https://en.wikipedia.org/wiki/Bordeaux_mixture https://en.wikipedia.org/wiki/Bordeaux_mixture (This one was invented after th

Certain biocides were a problem: https://en.wikipedia.org/wiki/Bordeaux_mixture https://en.wikipedia.org/wiki/Bordeaux_mixture (This one was invented after the Industrial Revolution started but it was used far away from most factories.)