Depends what you mean by inefficient. The other thing Knuth meant is that you should focus your efficiency energy first on overall design efficiency. Algorithmi

Depends what you mean by inefficient. The other thing Knuth meant is that you should focus your efficiency energy first on overall design efficiency. Algorithmic and other efficiencies are irrelevant if your design is bad and a bad design cannot be fixed by looking at the profiler and fixing hotspots