The case of Jesse Gelsinger comes to mind. https://en.wikipedia.org/wiki/Jesse_Gelsinger https://en.wikipedia.org/wiki/Jesse_Gelsinger The victim was a young

The case of Jesse Gelsinger comes to mind. https://en.wikipedia.org/wiki/Jesse_Gelsinger https://en.wikipedia.org/wiki/Jesse_Gelsinger The victim was a young kid which had 50+ years of life before him, and he was able to manage his condition fairly well prior to the experiment. Add some shady details in the informed consent process, and the reaction of the public to his death was so overwhelmingly negative that gene therapy took a massive hit.