I would say it is partially true. Expression of a gene (or even changes in its expression levels) may affect detrimentally the product of other genes. But, on t

I would say it is partially true. Expression of a gene (or even changes in its expression levels) may affect detrimentally the product of other genes. But, on the other hand, these changes can be compensated (for instance) by “beneficial” epistatic interactions coming from additional genes, allowing the individual to keep its phenotype. Biology is tangled and messy, after all.