3 ms·

> Curious about selectivity against 5-HT3 as well as the nausea can be a problem. That would be a nice feature aiui; some people I know got into the habit of a

by notamy 3y ago

> Curious about selectivity against 5-HT3 as well as the nausea can be a problem. That would be a nice feature aiui; some people I know got into the habit of always taking psychedelics with ondansetron to try to avoid the nausea.

bbqq 3y ago
Ginger is often suggested as well, which is another 5ht3 antagonist. I wonder if it's linked to susceptibility to motion sickness, which is known to be genetic, as neither psychedelics nor motion give me nausea at all.
- tbalsam 3y ago
  Yes, though thankfully ondnanestron has a shockingly good safety profile for a serotonergic antiemetic. That said, reducing that external complexity would be nice. CBD actual has some mild antiemesis properties as well and can be as immediately effective as Zofran if inhaled. I once backpacked with a dab pen and CBD due to having constant nausea, the crystal CBD isolate was easier to source and refill (since it's hemp derived) and the dab pen meant that I got nausea relief in seconds. Unfortunately CBD in ultra high doses can contribute to serotonin syndrome IIUC due to 5-HT1A activation (which is how it exerts anti-emetic effects IIUC/IIRC). So that of course is always a big problem and I think can make polypharmacy with it a bit more difficult (though I am of course not a doctor and this is not medical advice). That said CBD does help w.r.t. some social inhibitions due to autism IIRC and when I was dabbing between 300 mg - 1 g a day I definitely noticed a very calm, warm, low-key "peace" about the world that I very much appreciated. That was very nice indeed. Also, ginger can be nice for oral nausea as IIRC, however it does not cross the gut barrier as well so it takes more (and sometimes the spiciness can be a problem). It also inhibits a bunch of CYP enzymes as well which is something to consider (I guess many things do, but I tend to use it more as an emergency backup of emergency backups when I don't have anything else available to me. Order generally is Zofran -> CBD (200-300 mg sublingual if not urgent) -> Pepto -> Slightly more Pepto+Ginger depending upon urgency/availability. Refilling prescriptions can be a problem due to the overwhelm of autism for me, so I try to dole/parse it out sparing, at least as I am able to. <3 :')))) Happy to answer any questions, sorry this was an autistic infodump, really like this topic here.b<3 :'))))
LoganDark 3y ago
Nausea can also be a result of not having a safe, regulated source of psychedelics. You always end up having to trust some dude (or gal), and not all of them produce product in the same way or to the same standard of quality. If I could buy LSD from the store, then I wouldn't have to worry about getting an upset stomach due to impurities.
- foobiekr 3y ago
  You'd probably get one anyway due to that receptor activation.
  - LoganDark 3y ago
    I have used pure LSD before (quite regularly for months) and it does not cause me any stomach problems. I'm sure it can for some people, but it's not universal. Impure LSD, and some RC substitutes, often do cause stomach problems. They can also cause death.

by notamy 3y ago

bbqq 3y ago

Ginger is often suggested as well, which is another 5ht3 antagonist. I wonder if it's linked to susceptibility to motion sickness, which is known to be genetic, as neither psychedelics nor motion give me nausea at all.

tbalsam 3y ago
Yes, though thankfully ondnanestron has a shockingly good safety profile for a serotonergic antiemetic. That said, reducing that external complexity would be nice. CBD actual has some mild antiemesis properties as well and can be as immediately effective as Zofran if inhaled. I once backpacked with a dab pen and CBD due to having constant nausea, the crystal CBD isolate was easier to source and refill (since it's hemp derived) and the dab pen meant that I got nausea relief in seconds. Unfortunately CBD in ultra high doses can contribute to serotonin syndrome IIUC due to 5-HT1A activation (which is how it exerts anti-emetic effects IIUC/IIRC). So that of course is always a big problem and I think can make polypharmacy with it a bit more difficult (though I am of course not a doctor and this is not medical advice). That said CBD does help w.r.t. some social inhibitions due to autism IIRC and when I was dabbing between 300 mg - 1 g a day I definitely noticed a very calm, warm, low-key "peace" about the world that I very much appreciated. That was very nice indeed. Also, ginger can be nice for oral nausea as IIRC, however it does not cross the gut barrier as well so it takes more (and sometimes the spiciness can be a problem). It also inhibits a bunch of CYP enzymes as well which is something to consider (I guess many things do, but I tend to use it more as an emergency backup of emergency backups when I don't have anything else available to me. Order generally is Zofran -> CBD (200-300 mg sublingual if not urgent) -> Pepto -> Slightly more Pepto+Ginger depending upon urgency/availability. Refilling prescriptions can be a problem due to the overwhelm of autism for me, so I try to dole/parse it out sparing, at least as I am able to. <3 :')))) Happy to answer any questions, sorry this was an autistic infodump, really like this topic here.b<3 :'))))

LoganDark 3y ago

Nausea can also be a result of not having a safe, regulated source of psychedelics. You always end up having to trust some dude (or gal), and not all of them produce product in the same way or to the same standard of quality. If I could buy LSD from the store, then I wouldn't have to worry about getting an upset stomach due to impurities.

foobiekr 3y ago
You'd probably get one anyway due to that receptor activation.
- LoganDark 3y ago
  I have used pure LSD before (quite regularly for months) and it does not cause me any stomach problems. I'm sure it can for some people, but it's not universal. Impure LSD, and some RC substitutes, often do cause stomach problems. They can also cause death.