There's also `guix shell` which can be used in shebang position. Example from the Guix manual: #!/usr/bin/env -S guix shell python python-numpy -- python3

There's also `guix shell` which can be used in shebang position. Example from the Guix manual: #!/usr/bin/env -S guix shell python python-numpy -- python3 import numpy print("This is numpy", numpy.version.version) It also works with manifest files specifying more complex environments.