This seems like a fairly weak review, it just presents links to other papers with a lot of “might”s. I don’t see any meta-analysis computing actual harm. Eg “n

This seems like a fairly weak review, it just presents links to other papers with a lot of “might”s. I don’t see any meta-analysis computing actual harm. Eg “nicotine and cancer”: > In addition, nicotine is a precursor of tobacco specific nitrosamines (TSNAs), through nitrosation in the oral cavity.[32,33] It is shown that nitrosation of nicotine could lead to formation of NNN and NNK. This effect of nicotine may be important… As Gwern noted, the cardiovascular risks are nonzero, but it doesn’t seem like there is evidence of a strong effect for increasing cancer. (Still room for a weak effect I suppose.)