3 ms·
> There are at least three different pharmacological ways to induce hallucinations: (1) activation of dopamine D2 receptors (D2Rs) with psychostimulants, (2) ac
by clbrmbr 3y ago
> There are at least three different pharmacological ways to induce hallucinations: (1) activation of dopamine D2 receptors (D2Rs) with psychostimulants, (2) activation of serotonin 5HT2A receptors (HT2ARs) with psychedelics, and (3) blockage of glutamate NMDA receptors (NMDARs) with dissociative anesthetics.
I’m always surprised when the kappa-opioid pathway (salvinorin A) is overlooked. It produces very distinctive hallucinations. I lack the personal experience to judge, but I think it’s phenomenalogically distinct from other dissociate experiences. It should be easier to research given that Salvia diviniorum and its constituents are not controlled federally nor in many states.
- temp0826 3y agoA bit more dangerous recreationally but scopolamine (datura/brugmansia/etc) is hallucinogenic in yet another way (antimuscarinic, blocking acetylcholine receptors).
- tessellated 3y agoAlso, there are Kappa Opioid antagonists like Salvinorin A. Proceed with caution.
- beefman 3y agoSalvinorin A is a k-opioid agonist.
- Wherecombinator 3y agoI’m not familiar with pharmacology of salvia but taking it is quite dangerous compared to other hallucinogens. A number of my friends had terrible feelings and were freaked out for about a week afterwards. Similar stories are found on erowid.