> In 2021, Yaden and Griffiths proposed an experiment, the only definitive study that could disprove the importance of subjective effects: the administration of

> In 2021, Yaden and Griffiths proposed an experiment, the only definitive study that could disprove the importance of subjective effects: the administration of psychedelics to individuals rendered fully unconscious via deep anesthesia, and who subsequently reported no memory of the psychedelic experience. If full and lasting therapeutic efficacy remains under these conditions, the subjective effects — importantly, not limited to the mystical experience — would be proven irrelevant. The RECAP study, currently underway at the University of Wisconsin, is investigating a variant of this: whether the coadministration of midazolam, an amnesiac sedative, can effectively wipe participant’s memories of the subjective effects. Results are still forthcoming. Wonder when they’re going to get published. It’s been over 2 years by now.