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> Fasting gives you a dopamine dump to give you the energy to find food. The hunger-hormone ghrelin actually has substantial and broad benefits to health, incl

by xk_id 3y ago

> Fasting gives you a dopamine dump to give you the energy to find food. The hunger-hormone ghrelin actually has substantial and broad benefits to health, including an evolutionary sharpening of cognitive functions [1], albeit possibly at the cost of a narrowing of focus to food-related topics. The fast/feast cycle was recently found to recapitulate in humans the improvements in health biomarkers typically observed with caloric restriction, with less detrimental effects on the immune system and bone density [2]. Anyway the line between dietary restriction that improves health and an eating disorder is a fine and dangerous one. The difference is made by meticulously monitoring your micronutrient requirements to avoid any deficiencies. Assuming otherwise optimal nutrition, caloric + protein restriction is consistently associated with improvement in health biomarkers. But long-term human trials with hard endpoints like longevity and suitable controls don’t exist and are impractical. [1] https://pubmed.ncbi.nlm.nih.gov/27993602/ https://pubmed.ncbi.nlm.nih.gov/27993602/ [2] https://www.cell.com/cell-metabolism/fulltext/S1550-4131(19)30429-2 https://www.cell.com/cell-metabolism/fulltext/S1550-4131(19)...

MeImCounting 3y ago
There are certainly complicated physiological effects caused by fasting however the heterogeneity and limited number of studies make it difficult to draw definitive conclusions Mental deficits are associated with fasting across a review of a variety of studies https://pubmed.ncbi.nlm.nih.gov/34595721/ https://pubmed.ncbi.nlm.nih.gov/34595721/ Fasting can also cause other mental issues: "Additionally, fasting was found to be associated with alterations in mood, including worsened mood, heightened irritability, difficulties concentrating, and increased fatigue, as well as an increase in depressive score in mentally healthy humans" https://www.nature.com/articles/s41598-022-11639-1 https://www.nature.com/articles/s41598-022-11639-1 All in all it remains highly suspect that fasting has anything but long term and short term negative effects. As I said in another comment it makes sense to me that so called "health fasting" tends to be more common among people who are already vulnerable and at risk for disordered eating. I will continue to spread awareness about the link between "health fasting" (as well as other health and diet based fads) and actual life threatening eating disorders. There is a huge lack of research into eating disorders generally and even less research into the interaction of health fads and eating disorders. I encourage everyone to advocate and support any and all research in this area to combat misinformation spread by "health" gurus and companies looking to make a quick buck.
- xk_id 3y ago
  Well fasting is hardly a consumerist conspiracy, as that would be a contradiction. It’s likely that the downsides are a necessary trade off for a longer lifespan. The body reduces its metabolism in order to conserve resources and survive long enough until access to sustenance returns. The most dramatic change is the loss in libido; maintaining an active reproductive system has significant metabolic demands, so they are deprioritised. It’s possible that what we consider “healthy baseline” in the contemporary age of caloric abundance is actually a hyper-active state that accumulates rapid damage and dietary restriction brings metabolism down to a frugal and entropy-conserving state. Edit: those two fantastic papers should provide you with all the help you will ever need in your efforts: http://www2.hawaii.edu/~vitousek/CRAN2.pdf http://www2.hawaii.edu/~vitousek/CRAN2.pdf http://www2.hawaii.edu/~vitousek/CRAN1.pdf http://www2.hawaii.edu/~vitousek/CRAN1.pdf
  - MeImCounting 3y ago
    Critiques of caloric restriction (CR) studies include issues with control groups in animal research where these groups might eat more than usual complicating comparisons. Also, CR's benefits could vary based on eating habits and may not apply to everyone. There's a concern that extreme CR can weaken the immune system among other issues like bone density loss etc. The overall impact of CR on health and longevity clearly needs more research to be understood. While its undeniable that some of the strains of mice and fruit flies did live longer, extrapolating that to humans and associating that with "health fasting" is questionable at best. If this becomes a viable technique for human health and life extension it ought to be undertaken in a supervised and managed way with the assistance of health professionals. Not sold as a magic treat-yourself cure for all ailments on the internet. All in all CRL outside of an academic and scientific setting is almost certainly just going to spread dangerous misconceptions about health and our bodies. > "Well fasting is hardly a consumerist conspiracy, as that would be a contradiction." No fasting clearly isnt but most of these "health fasting" diet types also shill other dangerous "health" advice from juice "detoxes" to radioactive "aura cleansers" About that "CALERIE" trial: "many of them had BMIs that fall in the overweight category at the start of the trial. This means that any health benefits observed cannot be fully decoupled from the weight loss most participants experienced on their restricted diets. It is already well-known that going from being overweight to a healthy weight has a positive impact on the body; however, the trial results do not clearly answer the question of whether metabolic changes due to calorie reduction beyond a normal diet can improve health. Moreover, the trial was too short to determine the long-term effects, good or bad. " https://sitn.hms.harvard.edu/flash/2020/can-calorie-restriction-extend-your-lifespan/ https://sitn.hms.harvard.edu/flash/2020/can-calorie-restrict... So like I said above portraying this as somehow proven to be healthy in humans is a vast oversimplification of a complicated field and really isnt related to "health fasting" at all

by xk_id 3y ago

MeImCounting 3y ago

There are certainly complicated physiological effects caused by fasting however the heterogeneity and limited number of studies make it difficult to draw definitive conclusions Mental deficits are associated with fasting across a review of a variety of studies https://pubmed.ncbi.nlm.nih.gov/34595721/ https://pubmed.ncbi.nlm.nih.gov/34595721/ Fasting can also cause other mental issues: "Additionally, fasting was found to be associated with alterations in mood, including worsened mood, heightened irritability, difficulties concentrating, and increased fatigue, as well as an increase in depressive score in mentally healthy humans" https://www.nature.com/articles/s41598-022-11639-1 https://www.nature.com/articles/s41598-022-11639-1 All in all it remains highly suspect that fasting has anything but long term and short term negative effects. As I said in another comment it makes sense to me that so called "health fasting" tends to be more common among people who are already vulnerable and at risk for disordered eating. I will continue to spread awareness about the link between "health fasting" (as well as other health and diet based fads) and actual life threatening eating disorders. There is a huge lack of research into eating disorders generally and even less research into the interaction of health fads and eating disorders. I encourage everyone to advocate and support any and all research in this area to combat misinformation spread by "health" gurus and companies looking to make a quick buck.

xk_id 3y ago
Well fasting is hardly a consumerist conspiracy, as that would be a contradiction. It’s likely that the downsides are a necessary trade off for a longer lifespan. The body reduces its metabolism in order to conserve resources and survive long enough until access to sustenance returns. The most dramatic change is the loss in libido; maintaining an active reproductive system has significant metabolic demands, so they are deprioritised. It’s possible that what we consider “healthy baseline” in the contemporary age of caloric abundance is actually a hyper-active state that accumulates rapid damage and dietary restriction brings metabolism down to a frugal and entropy-conserving state. Edit: those two fantastic papers should provide you with all the help you will ever need in your efforts: http://www2.hawaii.edu/~vitousek/CRAN2.pdf http://www2.hawaii.edu/~vitousek/CRAN2.pdf http://www2.hawaii.edu/~vitousek/CRAN1.pdf http://www2.hawaii.edu/~vitousek/CRAN1.pdf
- MeImCounting 3y ago
  Critiques of caloric restriction (CR) studies include issues with control groups in animal research where these groups might eat more than usual complicating comparisons. Also, CR's benefits could vary based on eating habits and may not apply to everyone. There's a concern that extreme CR can weaken the immune system among other issues like bone density loss etc. The overall impact of CR on health and longevity clearly needs more research to be understood. While its undeniable that some of the strains of mice and fruit flies did live longer, extrapolating that to humans and associating that with "health fasting" is questionable at best. If this becomes a viable technique for human health and life extension it ought to be undertaken in a supervised and managed way with the assistance of health professionals. Not sold as a magic treat-yourself cure for all ailments on the internet. All in all CRL outside of an academic and scientific setting is almost certainly just going to spread dangerous misconceptions about health and our bodies. > "Well fasting is hardly a consumerist conspiracy, as that would be a contradiction." No fasting clearly isnt but most of these "health fasting" diet types also shill other dangerous "health" advice from juice "detoxes" to radioactive "aura cleansers" About that "CALERIE" trial: "many of them had BMIs that fall in the overweight category at the start of the trial. This means that any health benefits observed cannot be fully decoupled from the weight loss most participants experienced on their restricted diets. It is already well-known that going from being overweight to a healthy weight has a positive impact on the body; however, the trial results do not clearly answer the question of whether metabolic changes due to calorie reduction beyond a normal diet can improve health. Moreover, the trial was too short to determine the long-term effects, good or bad. " https://sitn.hms.harvard.edu/flash/2020/can-calorie-restriction-extend-your-lifespan/ https://sitn.hms.harvard.edu/flash/2020/can-calorie-restrict... So like I said above portraying this as somehow proven to be healthy in humans is a vast oversimplification of a complicated field and really isnt related to "health fasting" at all