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When sucralose is heated above 120C (e.g. baked in an oven) it breaks down into harmful organochlorene compounds, such as Polychlorinated Biphenyls similar in t

by 127361 3y ago

When sucralose is heated above 120C (e.g. baked in an oven) it breaks down into harmful organochlorene compounds, such as Polychlorinated Biphenyls similar in toxicity to 2,3,7,8-TCDD. 2,3,7,8-TCDD is one of the most toxic dioxins known. https://www.bfr.bund.de/cm/349/harmful-compounds-might-be-formed-when-foods-containing-the-sweetener-sucralose-are-heated.pdf https://www.bfr.bund.de/cm/349/harmful-compounds-might-be-fo...

wvenable 3y ago
I don't understand the uncertainty of this whole article. "It is unclear on the one hand which toxic reaction products are generated in detail and in which quantities they are formed" Is a microscopic bit of harmful chemical going to do anything? We are exposed to lots of harmful chemicals all the time. Even our cleaning products are harmful. https://en.wikipedia.org/wiki/The_dose_makes_the_poison https://en.wikipedia.org/wiki/The_dose_makes_the_poison Admittedly I'm not going to go around boiling sucralose and drinking it but I'm also not going to give this much more thought either.
- paulmd 3y ago
  > Is a microscopic bit of harmful chemical going to do anything? Dioxins are generally a class of chemical where the answer is yes. Even trace amounts are horrifically carcinogenic. In one instance, six truckloads of 2,3,7,8-TCDD-contaminated waste (not pure TCDD) mixed into used motor oil and spread over the roads of a ~420 acre town as dust control resulted in the entire town having to be permanently evacuated and disincorporated. https://en.wikipedia.org/wiki/Times_Beach,_Missouri https://en.wikipedia.org/wiki/Times_Beach,_Missouri Also, more generally, letting catchphrase-driven handwaves from industry about how their dumping is actually ok really isn't a great way to be. Things like dumping of low-level waste (ie not actual uranium or fission products, just ordinary furniture/materials from facilities that are mildly activated) off the coast of california have increasingly been realized to be a mistake. Even "diluted into a whole ocean" (it never is), it turns out it doesn't just go away, and the plumes are in fact both detectable and potentially harmful. You know what actually is the solution? The complete opposite, concentration and incineration (for dioxins) or permanent containment (high-level nuclear waste).
  - deleted 3y ago
    [deleted]
  - 127361 3y ago
    https://www.chemistryworld.com/news/digestion-of-artificial-sweetener-sucralose-appears-to-create-metabolite-that-damages-dna/4017552.article https://www.chemistryworld.com/news/digestion-of-artificial-... "Further, the team discovered that gut cells exposed to sucralose-6-acetate had increased activity in genes related to oxidative stress, inflammation and carcinogenicity. ‘It’s time to revisit the safety and regulatory status of sucralose, because the evidence is mounting that it carries significant risks,’ warned Susan Schiffman, the study’s corresponding author."

by 127361 3y ago

wvenable 3y ago

I don't understand the uncertainty of this whole article. "It is unclear on the one hand which toxic reaction products are generated in detail and in which quantities they are formed" Is a microscopic bit of harmful chemical going to do anything? We are exposed to lots of harmful chemicals all the time. Even our cleaning products are harmful. https://en.wikipedia.org/wiki/The_dose_makes_the_poison https://en.wikipedia.org/wiki/The_dose_makes_the_poison Admittedly I'm not going to go around boiling sucralose and drinking it but I'm also not going to give this much more thought either.

paulmd 3y ago
> Is a microscopic bit of harmful chemical going to do anything? Dioxins are generally a class of chemical where the answer is yes. Even trace amounts are horrifically carcinogenic. In one instance, six truckloads of 2,3,7,8-TCDD-contaminated waste (not pure TCDD) mixed into used motor oil and spread over the roads of a ~420 acre town as dust control resulted in the entire town having to be permanently evacuated and disincorporated. https://en.wikipedia.org/wiki/Times_Beach,_Missouri https://en.wikipedia.org/wiki/Times_Beach,_Missouri Also, more generally, letting catchphrase-driven handwaves from industry about how their dumping is actually ok really isn't a great way to be. Things like dumping of low-level waste (ie not actual uranium or fission products, just ordinary furniture/materials from facilities that are mildly activated) off the coast of california have increasingly been realized to be a mistake. Even "diluted into a whole ocean" (it never is), it turns out it doesn't just go away, and the plumes are in fact both detectable and potentially harmful. You know what actually is the solution? The complete opposite, concentration and incineration (for dioxins) or permanent containment (high-level nuclear waste).
- deleted 3y ago
  [deleted]
- 127361 3y ago
  https://www.chemistryworld.com/news/digestion-of-artificial-sweetener-sucralose-appears-to-create-metabolite-that-damages-dna/4017552.article https://www.chemistryworld.com/news/digestion-of-artificial-... "Further, the team discovered that gut cells exposed to sucralose-6-acetate had increased activity in genes related to oxidative stress, inflammation and carcinogenicity. ‘It’s time to revisit the safety and regulatory status of sucralose, because the evidence is mounting that it carries significant risks,’ warned Susan Schiffman, the study’s corresponding author."