I think it's possible. When you get down to the biology and chemistry the electrical action potential driving all this results in ion channels opening and closi

I think it's possible. When you get down to the biology and chemistry the electrical action potential driving all this results in ion channels opening and closing on both sides to pass on the signal. I totally believe individual dendrite-axon connections can lose or gain strength over time based on an optimization of the efficiency of these ion channels. I think this is above and beyond a simple mathematical weight and the nueron structures around these dendrite-axon pathways change or express their genes differently over time.