Maybe the biggest difference is that you can place virtual screens and windows arbitrarily as needed, rather than being restricted to parts of your desk where a

Maybe the biggest difference is that you can place virtual screens and windows arbitrarily as needed, rather than being restricted to parts of your desk where a stand or VESA mount can fit. So one could for example have the benefits of multiple screens while lounging or in the middle of a flight. Even at a desk, window/screen placement would be more flexible than otherwise possible.