Yes that giant truck hole opened by Wickard that has become a catch all that means the federal government can regulated anything However the actual wording is

Yes that giant truck hole opened by Wickard that has become a catch all that means the federal government can regulated anything However the actual wording is "to Regulate Commerce with foreign Nations, and among the several States", the original intent to was to give power to congress to regulate how commerce is conducted between the states, i.e prevent the coastal states from having tariffs against the internal states, and prevent the internal states from having export taxes on gains, etc etc etc The original intent was not to allow the congress regulate individual commercial transactions by citizens that happen to cross state lines.