5 ms·

Ugh. Please… You know, my grandfather was thin as a stick and lived to 99 and was as sharp as a tack. Muscles need energy. When you use energy you produce wast

Ugh. Please… You know, my grandfather was thin as a stick and lived to 99 and was as sharp as a tack. Muscles need energy. When you use energy you produce waste. The waste in the muscles case is reactive oxygen species,. If you can’t clear that waste, you will become sick and fatigued and have disease. If you increase muscle mass without making sure you’re getting rid of these reactive, oxygen species Muscle mass won’t do a thing for your longevity. If you want to live longer, balance your oxidative stress.

blitz_skull 3y ago
Bro. I can’t tell if this is a joke or not. Outliers are a thing, there’s a good book on them. Your personal anecdote to your grandfather does not flip the table on all the research that clearly and definitively proves otherwise. Beyond that, resistance training DOES combat stress. C’mon man. Some counter opinions just aren’t worth voicing.
- alienicecream 3y ago
  C'mon man, dude, bro just get with the program guy.
  - blitz_skull 3y ago
    This guy gets it.
- Podgajski 3y ago
  I want you to tell me who is not an outlier on a bell curve? How flat is the bell curve? How tall is it? Aren’t really most of us outliers?
foobarbaz33 3y ago
There's always 1 person anecdotes. Monohar the body builder and early Mr. Universe winner lived to 104. Continuing to lift to the very end. I'd wager he was the most mobile centenarian ever too.
- stinkytaco 3y ago
  No, seriously, I had an uncle that smoked 3 cigarettes a day and lived into his 90s. I've started smoking a pack a day and I'll live well past 100, right? I wish we, as humans, understood odds better. All health advice is about stacking the deck in your favor, but outliers always exist. I'd be more critical, except I'm sure there's some area where I apply a similar ignorance of the basics.
  - Podgajski 3y ago
    Yeah, everyone is an individual, that’s my point. You can treat us all as a mass, or the midpoint in a bell curve, but we’re not. And the majority of us will be outliers are on any bell curve
    - stinkytaco 3y ago
      > And the majority of us will be outliers are on any bell curve This cannot be possible, by definition. The majority of us will be within one standard deviation of the midpoint on a bell curve because that's how bell curves work. And that means basic evidence based health and fitness advice applies to the majority of us. Not bullshit like "oxidative stress".
      - Podgajski 3y ago
        Being a standard deviation away is not being in the mid point of the Bell curve.
jmauritz 3y ago
That some proper deep broscience I haven’t seen in years, “oxidative stress” nice!
- Podgajski 3y ago
  Listen, the Bros don’t even talk about oxidative stress. What do you think it is that oxidants cholesterol to cause coronary artery disease? What do you think triggers the DNA changes to cause cancer? https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5927356/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5927356/
  - kortex 3y ago
    You do understand that biology is complex and multifaceted, and aging/healing is more complex than "oxidative stress bad", right? The body does double/triple/n-tuple with almost every biomolecule. "Inflammation" (which isn't a single process) is widely vilified but it's absolutely necessary to grow and heal.
    - Podgajski 3y ago
      Of course, it’s complicated, but it’s simple as well. It’s just about Balance. Too much inflammation is bad. Too little is bad. we need just to balance them out, and it’s the same with oxidative stress. Reactive oxygen species kill pathogens but they can also kill us. We balanced them using enzymes, and these enzymes need enzymes and cofactors.
      - kortex 3y ago
        So then why are you being so contrarian? The overwhelming evidence supports the theory that a combination of strength and cardio training leads to better healthspans. And before you "correlation is not causation" yeah no duh, but the evidence is absolutely conclusive by now that exercise is better than not.
        Podgajski 3y ago
malfist 3y ago
I'm not entirely sure what "reactive, oxygen species" is, but I think you're talking about free radicals, which your body is quite capable of dealing with. If you can't deal with "reactive, oxygen species" from muscles, you can't live. Your heart is a muscle.
- Podgajski 3y ago
  Our bodies are quite capable of dealing with when we have the right nutrition and we don’t create too much oxidative stress. I can’t believe how little understanding there is of the impact of distress. Just being deficient in manganese, zinc and copper could increase superoxides to a point that starts creating DNA damage. And it’s funny that you don’t think reactive oxygen species damage heart muscles. If there’s too much of them that is. If there’s an imbalance that is. https://www.hindawi.com/journals/omcl/2020/5732956/# https://www.hindawi.com/journals/omcl/2020/5732956/# If you’re not exactly sure what reactive oxygen species are, then, why don’t you look them up before you make comments of what you know nothing about. If you’re making fun, about a stupid comma that Siri placed in my sentence then well, that’s just childish. And you’re not serious at all.
  - kortex 3y ago
    Strength training isn't the same as chronic distress though. Activity that uses muscles above current baseline leads to inflammation, which leads to hypertrophy and growth, which results in downregulation of inflammatory markers in the long term. The body upregulates anti-oxidant species in response to normal increases in oxidative stress. Yes, acute/extreme spikes in ROS generation is bad, but that's not what actually occurs in regular exercise. Tomes of papers support the connection between physical activity, reduced inflammation markers, and decreased all-cause mortality. Maybe you should actually take some courses in molecular biology, instead of googling some very basic high-level articles and over-generalizing to support your misguided point.
    - Podgajski 3y ago
      > Tomes of papers support the connection between physical activity, reduced inflammation markers, and decreased all-cause mortality Correlation, not causation. What the hell is muscle use above a curent baseline? What does that even mean? I’m pretty sure you’ve never taken a science class in your life.
ryanklee 3y ago
None of that makes any sense.

blitz_skull 3y ago

Bro. I can’t tell if this is a joke or not. Outliers are a thing, there’s a good book on them. Your personal anecdote to your grandfather does not flip the table on all the research that clearly and definitively proves otherwise. Beyond that, resistance training DOES combat stress. C’mon man. Some counter opinions just aren’t worth voicing.

alienicecream 3y ago
C'mon man, dude, bro just get with the program guy.
- blitz_skull 3y ago
  This guy gets it.
Podgajski 3y ago
I want you to tell me who is not an outlier on a bell curve? How flat is the bell curve? How tall is it? Aren’t really most of us outliers?

foobarbaz33 3y ago

There's always 1 person anecdotes. Monohar the body builder and early Mr. Universe winner lived to 104. Continuing to lift to the very end. I'd wager he was the most mobile centenarian ever too.

stinkytaco 3y ago
No, seriously, I had an uncle that smoked 3 cigarettes a day and lived into his 90s. I've started smoking a pack a day and I'll live well past 100, right? I wish we, as humans, understood odds better. All health advice is about stacking the deck in your favor, but outliers always exist. I'd be more critical, except I'm sure there's some area where I apply a similar ignorance of the basics.
- Podgajski 3y ago
  Yeah, everyone is an individual, that’s my point. You can treat us all as a mass, or the midpoint in a bell curve, but we’re not. And the majority of us will be outliers are on any bell curve
  - stinkytaco 3y ago
    > And the majority of us will be outliers are on any bell curve This cannot be possible, by definition. The majority of us will be within one standard deviation of the midpoint on a bell curve because that's how bell curves work. And that means basic evidence based health and fitness advice applies to the majority of us. Not bullshit like "oxidative stress".
    - Podgajski 3y ago
      Being a standard deviation away is not being in the mid point of the Bell curve.

jmauritz 3y ago

That some proper deep broscience I haven’t seen in years, “oxidative stress” nice!

Podgajski 3y ago
Listen, the Bros don’t even talk about oxidative stress. What do you think it is that oxidants cholesterol to cause coronary artery disease? What do you think triggers the DNA changes to cause cancer? https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5927356/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5927356/
- kortex 3y ago
  You do understand that biology is complex and multifaceted, and aging/healing is more complex than "oxidative stress bad", right? The body does double/triple/n-tuple with almost every biomolecule. "Inflammation" (which isn't a single process) is widely vilified but it's absolutely necessary to grow and heal.
  - Podgajski 3y ago
    Of course, it’s complicated, but it’s simple as well. It’s just about Balance. Too much inflammation is bad. Too little is bad. we need just to balance them out, and it’s the same with oxidative stress. Reactive oxygen species kill pathogens but they can also kill us. We balanced them using enzymes, and these enzymes need enzymes and cofactors.
    - kortex 3y ago
      So then why are you being so contrarian? The overwhelming evidence supports the theory that a combination of strength and cardio training leads to better healthspans. And before you "correlation is not causation" yeah no duh, but the evidence is absolutely conclusive by now that exercise is better than not.
      - Podgajski 3y ago

malfist 3y ago

I'm not entirely sure what "reactive, oxygen species" is, but I think you're talking about free radicals, which your body is quite capable of dealing with. If you can't deal with "reactive, oxygen species" from muscles, you can't live. Your heart is a muscle.

Podgajski 3y ago
Our bodies are quite capable of dealing with when we have the right nutrition and we don’t create too much oxidative stress. I can’t believe how little understanding there is of the impact of distress. Just being deficient in manganese, zinc and copper could increase superoxides to a point that starts creating DNA damage. And it’s funny that you don’t think reactive oxygen species damage heart muscles. If there’s too much of them that is. If there’s an imbalance that is. https://www.hindawi.com/journals/omcl/2020/5732956/# https://www.hindawi.com/journals/omcl/2020/5732956/# If you’re not exactly sure what reactive oxygen species are, then, why don’t you look them up before you make comments of what you know nothing about. If you’re making fun, about a stupid comma that Siri placed in my sentence then well, that’s just childish. And you’re not serious at all.
- kortex 3y ago
  Strength training isn't the same as chronic distress though. Activity that uses muscles above current baseline leads to inflammation, which leads to hypertrophy and growth, which results in downregulation of inflammatory markers in the long term. The body upregulates anti-oxidant species in response to normal increases in oxidative stress. Yes, acute/extreme spikes in ROS generation is bad, but that's not what actually occurs in regular exercise. Tomes of papers support the connection between physical activity, reduced inflammation markers, and decreased all-cause mortality. Maybe you should actually take some courses in molecular biology, instead of googling some very basic high-level articles and over-generalizing to support your misguided point.
  - Podgajski 3y ago
    > Tomes of papers support the connection between physical activity, reduced inflammation markers, and decreased all-cause mortality Correlation, not causation. What the hell is muscle use above a curent baseline? What does that even mean? I’m pretty sure you’ve never taken a science class in your life.

ryanklee 3y ago

None of that makes any sense.