3 ms·
Went digging a bit. It's a "small molecule" (C21-H20-N2-O5) and commercialy available at $10/mg[1]. Presumably this would come down quite a bit if it were w
by pmayrgundter 3y ago
Went digging a bit. It's a "small molecule" (C21-H20-N2-O5) and commercialy available at $10/mg[1]. Presumably this would come down quite a bit if it were widely stocked.
The studies say they are looking at doses of 10mg/kg[2]. Similar dosing to a pain pill.
On a first read, looks like a partial solution as it only delays onset of venom pathology for a day, tho not sure I'm interpreting that correctly.
Otoh, it looks like the pills can continue to be taken for many days.. so perhaps there's promise for the venom to be slowly metabolized somehow that isn't inhibited. Might also bring down the cost of antivenom if it's now feasible to funnel patients into central treatment over greater distances, so stocks could be better used.
[1]https://pubchem.ncbi.nlm.nih.gov/compound/155815#section=Chemical-Vendors https://pubchem.ncbi.nlm.nih.gov/compound/155815#section=Che...
[2]https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9695340/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9695340/
https://clinicaltrials.gov/study/NCT04996264 https://clinicaltrials.gov/study/NCT04996264