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AlphaFold did not solve protein folding. You can tell this is the case because it doesn’t correctly model structures with missense variants. AlphaFold is a hug
by carbocation 3y ago
AlphaFold did not solve protein folding. You can tell this is the case because it doesn’t correctly model structures with missense variants.
AlphaFold is a huge advance and people are extending it to try to tackle this (eg AlphaMissense) but to say it solved protein folding is hyperbolic.
- ProllyInfamous 3y ago>"AlphaFold can do in TEN MINUTES what a PhD dissertation required, fifteen years ago." Quoting a PhD immunologist from Texas, who uses AlphaFold daily.
- carbocation 3y agoAgreed - and this is not in tension with my comment whatsoever.
- Engineering-MD 3y agoIs that not the same as saying maths is solved thanks to spreadsheets/excel? All of science and technology is to some extent automation and increased speed of what used to be slow and laborious.
- ProllyInfamous 3y agoMy sincerest response is that we are now post-moore's-law[1]; instead of "transistor density doubling every 18 months," I have (over the past year of Perplexity.AI) more of the belief that "global intelligence will double every 18 months." Just my ¢¢ half-sanity. [1] Isn't a single hydrogen diatom just 1nm wide? How much smaller can transistor gates be safely assembled? Didn't we physically stop getting physically smaller around 14nm?