Look at it this way: Your body secrets a certain amount of hunger hormones. The GLP-1 drugs act in a way that blocks those hormones. (I'm greatly simplifying he

Look at it this way: Your body secrets a certain amount of hunger hormones. The GLP-1 drugs act in a way that blocks those hormones. (I'm greatly simplifying here.) In response, your body secretes more hormones, so you take more GLP-1 drugs. Increase until you reach a stable balance that adequately controls the hunger. Now, when you stop taking the GLP-1 drugs, you have a flood of surplus hunger hormones... and the hunger comes back with a vengeance. Plus, you probably haven't learned any effective coping skills for dealing with that hunger while taking the drug - so you're likely to revert to old lifestyle practices. Or at least that's my understanding. The endocrine system is complicated. However, mechanism aside, the data is clear that people regain the weight once they stop. There's a relevant study here: https://dom-pubs.onlinelibrary.wiley.com/doi/10.1111/dom.14725 https://dom-pubs.onlinelibrary.wiley.com/doi/10.1111/dom.147...