3 ms·
But it's not the case that "T3 is the active form" as you'll read in the literature, it's that the removed iodine is the active or useful thing. Supplementatio
by cperciva 3y ago
But it's not the case that "T3 is the active form" as you'll read in the literature, it's that the removed iodine is the active or useful thing.
Supplementation with T3 yields a rapid correction in bradycardia and hypothermia caused by hypothyroidism. We treat with T4 because it has a longer physiological halflife and thus yields more consistent serum levels; but the evidence is incredibly clear that it's T3 which is having an effect, not T4.
- phkahler 3y agoHow does the T3 produce the result? Is it possible that conversion to T2 - liberation of iodine - is what does it? I have not head of this condition so I'll do some reading. Also, does simple iodine supplementation help?
- cperciva 3y agoThe most common cause of hypothyroidism is the autoimmune destruction of the thyroid gland. No amount of Iodine helps; you need T3 (usually administered as T4 which is then converted to T3 endogenously).
- ufo 3y agohttps://en.wikipedia.org/wiki/Thyroid_hormone_receptor https://en.wikipedia.org/wiki/Thyroid_hormone_receptor https://www.thyroidmanager.org/chapter/cellular-action-of-thyroid-hormone/ https://www.thyroidmanager.org/chapter/cellular-action-of-th... T3 hormone binds to thyroid hormone receptors in the cell's nucleus, which regulates gene expression. These TH receptors are present all over the place; thyroid hormone has wide ranging effects on the body.