3 ms·
I am very hopeful that combination treatment is available today and is just being figured out for safety/efficacy in those who suffer with long covid. For exam
by thenerdhead 3y ago
I am very hopeful that combination treatment is available today and is just being figured out for safety/efficacy in those who suffer with long covid.
For example look at this study from Italy on antivirals + monoclonal antibodies:
https://www.mdpi.com/2079-6382/12/9/1460 https://www.mdpi.com/2079-6382/12/9/1460
14/15(93%) found viral clearance with a combined therapy.
13 patients were alive, asymptomatic, and negative for SARS-CoV-2 by 90 days. 2 passed away for other causes.
There are other existing literature on these things helping middle-aged people as well such as:
https://www.medscape.com/viewarticle/monoclonal-antibodies-new-treatment-long-covid-2023a1000wfa https://www.medscape.com/viewarticle/monoclonal-antibodies-n...
3 lives completely restored back to normal with the use of an existing monoclonal antibody just sitting on shelves.
https://www.sciencedirect.com/science/article/pii/S073567572300534X https://www.sciencedirect.com/science/article/pii/S073567572...
This isn't a perfect treatment that cures everyone, but the efficacy seems rather high and the safety profile already exists given how much this has been given in acute covid during the EUA.
Also there is an upcoming monoclonal antibody that just went into clinical trials for safety that acts like a "pan" mAb which can target all variants with high efficacy by regeneron(look for REGN17092 below):
https://investor.regeneron.com/static-files/a73a7d9c-591d-43e4-905f-6851ac1ff04e https://investor.regeneron.com/static-files/a73a7d9c-591d-43...
https://clinicaltrials.gov/study/NCT05923424?intr=REGN17092 https://clinicaltrials.gov/study/NCT05923424?intr=REGN17092
Finally, there have been some people participating in the AER002 clinical trial (closest to Lilly's bebtelovimab) where they are seeing complete reversal of symptoms. The challenge is that there is existing literature suggesting both cases where people get better permanently and some people only are better for the duration of the half-life of the drug.
Either way you look at it, treatments are looking closer than ever.