It’s been tested for decades. The issue is protein-based platforms deliver the protein outside the cell. This means most do not get processed and presented by M

It’s been tested for decades. The issue is protein-based platforms deliver the protein outside the cell. This means most do not get processed and presented by MHC-1 and 2 the way a genetically encoded therapeutic does. The issue with DNA is it separates the innate immune activation signal (eg cGAS and TLRs) from the presentation so you don’t get co-signaling. This may be the ticket why mRNA could work…