The Crick in London is maybe a better example. As I understand it there you apply to work on treatment or understanding a specific human disease and you receive

The Crick in London is maybe a better example. As I understand it there you apply to work on treatment or understanding a specific human disease and you receive a one time 7 year grant which provides a stipend for you, two Ph.D. studentships and one lab assistant + a sum to equip your lab and access to a bunch of services (mice, bugs, fish, compute, chemicals...) You can get a single renewal - but that's all. No matter what you are done after 14 years.