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I don't believe it much matters. The original claim was having a controlled dose matters, so it not only matters, that's the whole conversation here. The deat

I don't believe it much matters. The original claim was having a controlled dose matters, so it not only matters, that's the whole conversation here. The death stats on oxycodone are staggering You make these claims about stats but don't give stats. but given free access to oxycodone People don't have free access oxycodone you're just as likely to die This is not verum. "16 million individuals worldwide have had or currently suffer from opioid use disorder (OUD)" https://www.ncbi.nlm.nih.gov/books/NBK448203/ https://www.ncbi.nlm.nih.gov/books/NBK448203/ Remember as well that a great many street fentanyl deaths were pts started on regulated, labeled opioids Primis, this is an unbacked claim. Secundo, why didn't they die from prescription opiods? The truth is fentanyl has a low safety index which makes the dose more important. "The calculated safety index (ORantinociception/ORrespiratory depression) for fentanyl of 1.20 suggests that fentanyl has a low safety margin, implicating that fentanyl needs to be titrated with caution." https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2190336/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2190336/

tptacek 3y ago
More people die from oxycodone, even today, I think? than from heroin. Labeled regulated opioids are not safe.
- CyberDildonics 3y ago
  Now you're way off the map. The originem claim was that controlled fentanyl dose would decrease overdoses. It wasn't about oxycodone being 'safe' (even though I gave you stats that showed 80% of deaths of from combining drugs), it wasn't about oxycodone vs heroin. Not to mention that way more people take oxycodone than heroin, so even from a stats 101 angle this doesn't make sense. Really, what is the point of a reply like this?
  - tptacek 3y ago
    I don't think I am. The subtext of the original comment was that making opiates more widely available but more carefully regulated as to content and dosage would save lives. It pretty clearly would not do that. The high order bit of this problem is the number of people that start habitually using opiates; I think basically nothing else matters.
    - CyberDildonics 3y ago
      It pretty clearly would not do that. Clear according to what? You gave no statistics and made nothing but unbacked claims. Most of what you did say is directly contradicted by the CDC. Fentanyl is extremely potent and has a very narrow window between therapeutic dose and an overdose that kills you. Other opiate cause deaths overwhelmingly only when combined with other drugs. Everything you have said about increased use or more deaths is an assumption not based on data. Why won't you source your claims?

tptacek 3y ago

More people die from oxycodone, even today, I think? than from heroin. Labeled regulated opioids are not safe.

CyberDildonics 3y ago
Now you're way off the map. The originem claim was that controlled fentanyl dose would decrease overdoses. It wasn't about oxycodone being 'safe' (even though I gave you stats that showed 80% of deaths of from combining drugs), it wasn't about oxycodone vs heroin. Not to mention that way more people take oxycodone than heroin, so even from a stats 101 angle this doesn't make sense. Really, what is the point of a reply like this?
- tptacek 3y ago
  I don't think I am. The subtext of the original comment was that making opiates more widely available but more carefully regulated as to content and dosage would save lives. It pretty clearly would not do that. The high order bit of this problem is the number of people that start habitually using opiates; I think basically nothing else matters.
  - CyberDildonics 3y ago
    It pretty clearly would not do that. Clear according to what? You gave no statistics and made nothing but unbacked claims. Most of what you did say is directly contradicted by the CDC. Fentanyl is extremely potent and has a very narrow window between therapeutic dose and an overdose that kills you. Other opiate cause deaths overwhelmingly only when combined with other drugs. Everything you have said about increased use or more deaths is an assumption not based on data. Why won't you source your claims?