> I think the main approach to prevent antibiotic resistance is coming up with a way to prevent bacteria ever coming across a low dose of the antibiotic (...)

> I think the main approach to prevent antibiotic resistance is coming up with a way to prevent bacteria ever coming across a low dose of the antibiotic (...) That's not the only way. We have more ways: * use low dose of antibiotic to kill enough bacteria to let the immune system to deal with the rest. Then ensure the subject is cured until all bacteria are killed so that none escape. Low dose might be needed because most antibiotics are actually pretty harmful and the harm is managed with low dose. * use more than one antibiotic in combination with the idea there is very little chance bacteria will gain resistance to both of them at the same time. * use the antibiotic only as a last resort. This is especially useful for bacterias that are not very harmful normally, but might become harmful for certain subjects (for example, immunosuppressed). If a bacteria with resistance escapes, the resistance might not be very useful advantage in outside environment where people do not need any help to fight off infection or when infection can be more routinely treated with another antibiotic. Again, these are our current strategie