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That's really interesting, what would be the mechanism of action for a headache induced by consciously imperceptible levels of marijuana in the air? I see this

by j4yav 3y ago

That's really interesting, what would be the mechanism of action for a headache induced by consciously imperceptible levels of marijuana in the air? I see this comment often so I believe you, I just haven't been able to conceive of how that would actually work but such a strong physiological reaction from such a tiny amount is really interesting. What happens if you are exposed to higher concentrations, is it a medical emergency of some kind? And what specifically happens? I'd love to learn more.

nataliste 3y ago
I have this reaction, but only when returning after a hard run. No exercise? Totally fine. Smells like skunky basil. If I've been on a run? Nausea, headache and it smells awful.
wizzwizz4 3y ago
It's not consciously-imperceptible levels, it's just not a particularly salient sensation. I notice the headache, then I notice the smell, and my brain helpfully informs me "hey, you've been smelling that for, like, the past 30 seconds". If the air's really cold, sometimes I don't smell anything until I warm up the air I'm breathing – but that's not imperceptible levels, that's just my nose not working in the cold. If I'm paying attention to what I'm smelling, I can stop breathing before I get a lungful, and that usually avoids any negative effects. But there are a lot of smells in a city, and I haven't developed reflexes for marijuana like I have for tobacco. When I'm exposed to higher concentrations, either I get a stronger headache, or the headache goes away and I get light-headed. I haven't died yet, so I don't think it's a medical emergency of any kind. I don't even know if it's because of the marijuana. Perhaps the breeze is concentrating a load of (e.g.) carbon monoxide in certain places, and it just happens to also concentrate marijuana scent… but I think it's probably the marijuana. https://www.durham.ac.uk/research/current/research-news/three-reasons-why-strong-perfumes-give-you-a-headache/ https://www.durham.ac.uk/research/current/research-news/thre... has some possible explanations: > The chemicals that activate the smell signals in our brain (called odorants) can sometimes irritate our sinuses. Smoke, perfume and chlorine are some of the most common odorants that cause irritation. > When [the trigeminal] pathway is stimulated it causes inflammation because it detects a threat that only the immune system can sort out. This, too, can lead to a headache. Chemical smells such as formaldehyde, certain cleaning products and cigarette smoke are all known to act directly on the trigeminal pathway. Some cannabinoids are known to act on the trigeminal pathway, and I don't usually get headaches from smoke, so it might be that… but I haven't run any experiments, so who knows?
- drewcoo 3y ago
  > I don't even know if it's because of the marijuana. Perhaps the breeze is concentrating a load of carbon monoxide in certain places, and it just happens to also concentrate marijuana scent… but I think it's probably the marijuana. Could also be hypochondria. Hypochondria isn't a personal choice and there is no blame in that suggestion.
  - fragmede 3y ago
    We don't get to choose what our brains do sometimes. "It's all in your head" is a dismissive explanation, except that we all have to live in our own heads, so if something is "in our head", it's a freaking big deal because we have to live with it rattling around in there. For someone with an mental disorder, the idea that wifi will cause cancer could force them to live on the fringes of society.
  - deleted 3y ago
    [deleted]

by j4yav 3y ago

nataliste 3y ago

I have this reaction, but only when returning after a hard run. No exercise? Totally fine. Smells like skunky basil. If I've been on a run? Nausea, headache and it smells awful.

wizzwizz4 3y ago

It's not consciously-imperceptible levels, it's just not a particularly salient sensation. I notice the headache, then I notice the smell, and my brain helpfully informs me "hey, you've been smelling that for, like, the past 30 seconds". If the air's really cold, sometimes I don't smell anything until I warm up the air I'm breathing – but that's not imperceptible levels, that's just my nose not working in the cold. If I'm paying attention to what I'm smelling, I can stop breathing before I get a lungful, and that usually avoids any negative effects. But there are a lot of smells in a city, and I haven't developed reflexes for marijuana like I have for tobacco. When I'm exposed to higher concentrations, either I get a stronger headache, or the headache goes away and I get light-headed. I haven't died yet, so I don't think it's a medical emergency of any kind. I don't even know if it's because of the marijuana. Perhaps the breeze is concentrating a load of (e.g.) carbon monoxide in certain places, and it just happens to also concentrate marijuana scent… but I think it's probably the marijuana. https://www.durham.ac.uk/research/current/research-news/three-reasons-why-strong-perfumes-give-you-a-headache/ https://www.durham.ac.uk/research/current/research-news/thre... has some possible explanations: > The chemicals that activate the smell signals in our brain (called odorants) can sometimes irritate our sinuses. Smoke, perfume and chlorine are some of the most common odorants that cause irritation. > When [the trigeminal] pathway is stimulated it causes inflammation because it detects a threat that only the immune system can sort out. This, too, can lead to a headache. Chemical smells such as formaldehyde, certain cleaning products and cigarette smoke are all known to act directly on the trigeminal pathway. Some cannabinoids are known to act on the trigeminal pathway, and I don't usually get headaches from smoke, so it might be that… but I haven't run any experiments, so who knows?

drewcoo 3y ago
> I don't even know if it's because of the marijuana. Perhaps the breeze is concentrating a load of carbon monoxide in certain places, and it just happens to also concentrate marijuana scent… but I think it's probably the marijuana. Could also be hypochondria. Hypochondria isn't a personal choice and there is no blame in that suggestion.
- fragmede 3y ago
  We don't get to choose what our brains do sometimes. "It's all in your head" is a dismissive explanation, except that we all have to live in our own heads, so if something is "in our head", it's a freaking big deal because we have to live with it rattling around in there. For someone with an mental disorder, the idea that wifi will cause cancer could force them to live on the fringes of society.
- deleted 3y ago
  [deleted]